Micky van de Ven Brace Ends Everton's Run at Brand New Stadium
The Dutch defender became the first defender to net twice in a English top-flight match for Tottenham since Jan Vertonghen in spring 2013.
At a glance
Micky Van de Ven heads home twice in opening period
Everton's Jake O'Brien has goal disallowed after VAR review
Senegalese midfielder nets final goal in dying moments
This loss is Everton's initial at their new ground
The Tottenham defender scored twice as Tottenham prolonged their winning streak in away games in the top division and delivered the Toffees their initial loss at Hill Dickinson Stadium.
Everton were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having left Goodison Park behind after 133 years at the end of the previous campaign.
But Spurs captain Van de Ven struck on two occasions from set-pieces in the opening 45 minutes to put their impressive record at risk, and they were failed to mount a comeback before Pape Matar Sarr - set up by ex-Everton forward Richarlison - nodded in a third to put the game to bed.
The Everton defender believed he had levelled the scores five minutes after Van de Ven's first goal, glancing a powerful header past Guglielmo Vicario from an set-piece.
Beto, meanwhile, missed a number of chances, while the Italian goalkeeper made a series of excellent saves to ensure Tottenham went five matches on the road without defeat in the Premier League.
But the video assistant referee intervened, advising Craig Pawson to check the score on the pitchside monitor and the referee ruled that the winger and Iliman Ndiaye were in offside positions and had impeded with the Spurs keeper.
The win moves Thomas Frank's side up to third in the Premier League, a handful of points off north London rivals and table-toppers the Gunners.
Everton stay 14th and sit half a dozen points ahead of the relegation zone.
Spurs breakdown: The defender excels in role at both ends of pitch
After a drab midweek performance in the Champions League against Monaco, where they mustered a mere two shots on goal, the manager opted for the French striker up front instead of ex-Everton forward the Brazilian.
The summer signing was failed to influence the game before being substituted for the substitute after an hour on the pitch, but it turns out he proved unnecessary in the final outcome.
Defender Van de Ven transformed into an offensive threat to be feared.
Tottenham's first goal came from a well-worked set-piece play, with the midfielder directing the ball toward the six-yard box for an unmarked the defender to head home.
And Ven de Ven - filling in as skipper in Cristian Romero's absence - notched his next goal in added time as he rose above the England keeper to head home.
The Dutchman was just as impressive in defence, combining effectively with Kevin Danso as the pair handled excellently with the 34 crosses thrown their way by Everton.
Toffees breakdown: Toffees missing striker's instinct
The club's recent stadium had been a fortress, but it seems the novelty may have faded somewhat and fans headed to the gates after Sarr's final goal for Spurs.
The break in Everton's unbeaten home run will not be a major concern for the manager, but their attacking woes will be.
The forward and Thierno Barry - the Toffees' two recognised centre-forwards - had netted only one league goal between them before the weekend's match.
And they were unable to add to that miserable record on a damp and dreary night on in Liverpool.
The striker's form was epitomized when he chose to bicycle-kick a golden opportunity from near the goal, even with having room and opportunity to readjust for a more conventional attempt that would have tested the keeper.
Barry, as well, was unable to make an impact after coming on for Beto in the second half.
It wasn't for a lack of opportunity. Most of Everton's offensive moves came through the winger and Ndiaye, who relentlessly delivered threatening crosses into the Tottenham penalty area.
Upcoming fixtures for these two sides?
Everton: Moyes' men travel to Sunderland in the Premier League on Monday, 3 November at 8 PM.
Spurs: The London club go to Newcastle's ground on late October for their next round League Cup match against Newcastle.